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{"id":2042,"date":"2023-06-03T12:55:13","date_gmt":"2023-06-03T15:55:13","guid":{"rendered":"https:\/\/sciencearena.org\/?p=2042"},"modified":"2023-06-01T16:58:40","modified_gmt":"2023-06-01T19:58:40","slug":"the-history-of-dengue","status":"publish","type":"post","link":"https:\/\/consult.puntocomm.com.br\/en\/news\/the-history-of-dengue\/","title":{"rendered":"The history of dengue"},"content":{"rendered":"\n<p>Until the early twentieth century, dengue was confused with other diseases, such as influenza. Not because of its causes, but because of its symptoms. The history of dengue remained unclear until it became widespread in Brazil in the 1980s, making it a greater focus of research in the country.<\/p>\n\n\n\n<p>In an effort to understand the process triggered by the 1986 dengue epidemic in Rio de Janeiro and its contribution to systematic research on the virus at the Oswaldo Cruz Institute (IOC-FIOCRUZ), health historian Jorge Tibilletti de Lara conducted an <a href=\"https:\/\/www.scielo.br\/j\/hcsm\/a\/YZw5KwtYnqFFLMBnLhwvYyq\/?lang=pt\" target=\"_blank\" rel=\"noreferrer noopener\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-green-cyan-color\">analysis that was published in an issue of the journal <em>Hist\u00f3ria, Ci\u00eancias, Sa\u00fade \u2013 Manguinhos<\/em> (History, science, health \u2013 Manguinhos)<\/mark><\/a>.<\/p>\n\n\n\n<p>\u201cThere is the history of the virus\u2019s identification, with its arrival in Brazil first confirmed in Boa Vista, Roraima, in 1981. Then in Nova Igua\u00e7u, Rio de Janeiro, in 1986. Then there is the clinical history of the disease, which is much less clear,\u201d says Lara, who is studying a PhD in the History of Science and Health at FIOCRUZ&#8217;s Casa de Oswaldo Cruz.<\/p>\n\n\n\n<p>\u201cThat\u2019s why I\u2019m looking at the role of virological studies that aimed to understand the disease, taking into account the relationship between physicians and virologists.\u201d The work\u2014the result of Lara&#8217;s master&#8217;s degree\u2014seeks to demonstrate the role played by dengue studies in shedding light on the disease at a time when it was still relatively unknown and was transitioning from a rare disease to a more common one.<\/p>\n\n\n\n<p>The article analyzes the main impacts of the disease on the research center, the career of scientists, the incorporation of new laboratory techniques for studying arboviruses, and the role of virology in new public health problems.<\/p>\n\n\n\n<p>\u201cArboviruses have a complex cycle that was discovered by virologists, resulting in clarification of the disease and the incorporation of new laboratory tests and methods, leading to a level of expertise in Brazilian virology that continues to this day,\u201d writes Lara in the article.<\/p>\n\n\n\n<p>In the 1980s, dengue was not even on the radar of most doctors and scientists\u2014at least not in Brazil\u2014although serious epidemics of the disease had occurred, such as in Havana, Cuba, in 1981.<\/p>\n\n\n\n<p>\u201cThe differentiation, including between dengue and chikungunya, for example, was made in the lab,\u201d explains the historian. &#8220;It was through isolation and identification of the viruses, which began in the 1950s, that clearer boundaries were revealed between these diseases. But this wasn\u2019t reflected in clinical settings because they were not diagnosed in patients until at least the 1980s.\u201d<br><br>According to Lara, although drawing parallels with other diseases (such as Zika, chikungunya, and COVID-19) is a \u201crisky maneuver,\u201d the perception of correlations between their trajectories over time is inevitable. There is a close relationship between the history of diseases transmitted by the mosquito <em>Aedes aegypti<\/em>, such as dengue, Zika, chikungunya, and yellow fever, both in identification of the viruses and in the establishment of diagnostic models.<\/p>\n\n\n\n<p>Yellow fever, for example, served as a model for dengue studies when they were started in Brazil, because of its long history of consolidated research and the similarities between the two diseases and viruses. Similarly, when Zika emerged in Brazil, studies on dengue became references for new research.<\/p>\n\n\n\n<p>With regard to COVID-19\u2014which is viral in origin but not transmitted by mosquitoes\u2014the article highlights that the speed of the research carried out by FIOCRUZ virologists and specialists nationwide when the pandemic began can be attributed at least partly to the expertise the country developed while studying the dengue virus.<\/p>\n\n\n\n<p>\u201cFIOCRUZ has historically operated in response to social demand\u2014epidemics, vaccination, serums, etc.\u2014through solid lines of biomedical research. This process was first highlighted in the 1970s by historian Nancy Stepan and is observable at the institution in various periods,\u201d explains Lara.<\/p>\n\n\n\n<p>As dengue established itself as a new urban arbovirus on a continental scale, a <a href=\"https:\/\/periodicos.unespar.edu.br\/index.php\/nupem\/article\/view\/5666\" target=\"_blank\" rel=\"noreferrer noopener\"><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-vivid-green-cyan-color\">cooperative Pan-American effort<\/mark><\/a>began, with scientists working closely together across Latin America, says Gabriel Lopes, who has a PhD in the History of Science and Health from Casa de Oswaldo Cruz and the Department of the History of Medicine at Johns Hopkins University, USA. &#8220;In Brazil, from 1986 onwards, a close dialogue was developed with Cuban scientists who had successfully faced an unprecedented dengue epidemic back in 1981,\u201d Lopes explains.<\/p>\n\n\n\n<h4 class=\"wp-block-heading has-vivid-cyan-blue-color has-text-color\">The history of science<\/h4>\n\n\n\n<p>Lara&#8217;s work is part of a research field called the history of science, which is closely linked to the history of health. These are \u201csubdivisions\u201d of history that focus on analyzing the historical characteristics that form what we know today as science.<\/p>\n\n\n\n<p>In the history of health, historians seek to understand the interrelated cultural, political, social, and scientific processes behind the history of diseases, doctors, patients, vaccination campaigns, hospitals, and more.<\/p>\n\n\n\n<p>In Brazil, as in the rest of the world, viruses were studied even before the existence of the consolidated discipline known as \u201cvirology.\u201d Smallpox and yellow fever were the main diseases of viral origin studied in this context between the end of the nineteenth century and the early twentieth century.<\/p>\n\n\n\n<p>The nation\u2019s expertise on these biological entities was then developed throughout the twentieth century, with a greater focus after the 1950s in response to several epidemics of infectious diseases. And it changed with the emergence of certain scientific techniques and instruments.<\/p>\n\n\n\n<p>Institutional and political factors and milestones, such as the 1964 military coup and the country\u2019s redemocratization in 1985, also played a major role. All these processes directly affected the formation of research groups and the careers of many scientists.<\/p>\n\n\n\n<p>Thus, when dengue appeared in 1986, although virology labs such as the Evandro Chagas Institute in Par\u00e1 and the Oswaldo Cruz Institute already had extensive experience in studying viruses, dengue\u2019s novelty and the challenge of understanding the mechanisms of a newly circulating virus, especially as a complex arbovirus (transmitted by arthropods), resulted in much new research in virology. This led to the development of new tools for the scientific discipline, including increased funding and visibility and dedicated departments and research groups.<\/p>\n\n\n\n<p>The Brazilian Society of Virology (SBV) was created that same year of 1986, as was the Flavivirus Laboratory at FIOCRUZ\u2019s Virology Department, where the dengue virus was isolated and continues to be systematically studied to this day.<\/p>\n\n\n\n<p>\u201cIn this sense, I would say that dengue gave Brazilian virology significant experience, having become one of the main topics studied in the field alongside other arboviruses, as well as providing an excellent model for the study of other viruses,\u201d says Lara, who is currently writing his doctoral thesis on the applications of radioisotopes in Brazilian biology research in the second half of the twentieth century.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>New article describes the role of virological studies in understanding the disease\u2019s evolution in Brazil<\/p>\n","protected":false},"author":2,"featured_media":1971,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"footnotes":""},"categories":[85],"tags":[],"autor":[98],"temas":[],"chapeu":[193],"class_list":["post-2042","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","autor-ricardo-muniz-2","chapeu-virology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v20.9 - 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